Gliclazide (21187-98-4)
List List
Gliclazide ndi mankhwala ochepetsa shuga a sulfonylurea.Ndi ufa wa crystalline woyera kapena crystalline, wopanda fungo komanso wosakoma.
Gliclazide ndi m'badwo wachiwiri wa sulfonylurea hypoglycemic wothandizira wokhala ndi mphamvu.Njira yake ndi yofanana ndi ya toluenosulfonylurea, mwachitsanzo, imagwira ntchito pama cell a pancreatic β-cell kuti ipititse patsogolo katulutsidwe ka insulini ndikuwonjezera kutulutsa kwa insulini mutatha kudya shuga, zomwe sizingangowonjezera kagayidwe kake ka odwala omwe ali ndi matenda a shuga, komanso kusintha kapena kuchedwetsa katulutsidwe ka shuga. matenda a diabetesic vascular complications.
Gliclazide imagwiritsidwa ntchito makamaka pa matenda a shuga a mtundu wachiwiri wofatsa komanso wocheperako womwe umayambira akulu pomwe kuwongolera zakudya ndi masewera olimbitsa thupi kokha sikuthandiza komanso popanda chizolowezi cha ketosis, komanso kumathandizira zotupa za fundus komanso kusokonezeka kwa metabolic ndi mtima mwa odwala matenda ashuga.
Kugwiritsa ntchito
Gliclazide imagwiritsidwa ntchito powongolera hyperglycemia mu shuga mellitus wokhazikika, wofatsa, wopanda ketosis, mtundu 2 wa shuga.Amagwiritsidwa ntchito ngati matenda a shuga sangathe kuwongoleredwa ndi kadyedwe koyenera komanso kuchita masewera olimbitsa thupi kapena ngati chithandizo cha insulin sichili choyenera. "National Kidney Foundation imati Gliclazide safuna kukweza mlingo ngakhale atadwala matenda a impso.
| Yesani | Zofotokozera | Zotsatira za kusanthula |
| Maonekedwe | White kapena pafupifupi woyera ufa. | White ufa |
| Kusungunuka | Pafupifupi osasungunuka m'madzi;kusungunuka momasuka mu methylene chloride;sungunuka pang'ono mu acetone;amasungunuka pang'ono mu ethanol (96 peresenti). | Imakwaniritsa zofunikira |
| Zizindikiro | Mayamwidwe a infrared amagwirizana ndi omwe amapezeka ndi gliclazide CRS. | Imakwaniritsa zofunikira |
| Chidebe B (Wolemba HPLC) | ≤2 ppm | 0.5 ppm |
| Zitsulo zolemera | ≤10ppm | <10ppm |
| Zogwirizana (Wolemba HPLC) | Chidetso F ≤0.1% | Zosazindikirika |
| Chidetso chilichonse chosadziwika bwino ≤0.10% | 0.04% | |
| Chiwerengero cha zonyansa kupatula F ≤0.2% | 0.11% | |
| Kutaya pakuyanika | ≤0.25% | 0.11% |
| Phulusa la Sulfated | ≤0.1% | 0.03% |
| Zosungunulira zotsalira (Wolemba GC) | Ethyl acetate NMT 2500 ppm | 265ppm |
| N,N-Dimethylformamide NMT 880 ppm | Zosazindikirika | |
| Kuyesa | 99.0-101.0%, pa zouma. | 100.0% |
| Mapeto | Zotsatira za mayeso zikugwirizana ndi EP8. | |
