Homocysteine (HCY)
Kufotokozera
Homocysteine (HCY) amagwiritsidwa ntchito kuzindikira homocysteine m'magazi amunthu.Homocysteine (Hcy) ndi sulfure wokhala ndi amino acid opangidwa ndi metabolism ya methionine.80% ya Hcy imamangiriridwa ku mapuloteni kudzera m'magulu a disulfide m'magazi, ndipo gawo laling'ono chabe la homocysteine yaulere limagwira nawo ntchito.Miyezo ya Hcy imagwirizana kwambiri ndi matenda amtima.ndizofunikira kwambiri pachiwopsezo cha matenda amtima.Kuwonjezeka kwa Hcy m'magazi kumapangitsa kuti khoma la mitsempha ya magazi liwonongeke, zomwe zimayambitsa kutupa ndi kupanga zolembera pakhoma la chotengera, zomwe pamapeto pake zimabweretsa kutsekeka kwa magazi mu mtima.Odwala omwe ali ndi hyperhomocystinuria, kuwonongeka kwakukulu kwa majini kumakhudza kagayidwe ka Hcy, zomwe zimapangitsa hyperhomocysteinemia.Kuperewera kwa chibadwa kapena kuperewera kwa zakudya m'thupi la mavitamini a B kudzatsagana ndi kukwera kwapang'onopang'ono kapena pang'ono kwa Hcy, zomwe zidzawonjezera chiopsezo cha matenda a mtima.Hcy yokwezeka imatha kuyambitsanso zilema zobadwa monga neural chubu defects ndi congenital malformations.
Kapangidwe ka Chemical
Mfundo yoyesera
Oxidized Hcy imasinthidwa kukhala Hcy yaulere, ndipo Hcy yaulere imakhudzidwa ndi serine pansi pa catalysis ya CBS kupanga L-cystathionine.L-cystathionine imapanga Hcy, pyruvate ndi NH3 pansi pa catalysis ya CBL.Piruvate yopangidwa ndi machitidwe ozungulirawa imatha kuzindikirika ndi lactate dehydrogenase LDH ndi NADH, ndipo kutembenuka kwa NADH kukhala NAD kumagwirizana mwachindunji ndi zomwe zili mu Hcy mu zitsanzo.
Mayendedwe ndi kusunga
Mayendedwe:2-8 ° C
Nthawi yosungira ndi yovomerezeka:Ma reagents osatsegulidwa ayenera kusungidwa pa 2-8 ° C mumdima, ndipo nthawi yovomerezeka ndi miyezi 12;mutatha kutsegulidwa, ma reagents ayenera kusungidwa mumdima pa 2-8 ° C, ndipo nthawi yovomerezeka ndi mwezi umodzi popanda kuipitsa;ma reagents sayenera kuzizira.
Zindikirani
Zofunikira zachitsanzo: Chitsanzo ndi seramu yatsopano kapena plasma (heparin anticoagulation, 0.1mg heparin imatha anticoagulate 1.0ml magazi).Chonde tsitsani madzi a m'magazi mwamsanga mutangotenga magazi, kapena refrigerate ndi centrifuge mkati mwa ola limodzi.
