Glucose-6-phosphate dehydrogenase (G6PDH)

Kuperewera kwa Glucose 6 phosphate dehydrogenase (G6PD) ndi chikhalidwe chobadwa nacho chomwe maselo ofiira a m'magazi amawonongeka (hemolysis) pamene thupi likukumana ndi zakudya zina, mankhwala, matenda kapena kupsinjika maganizo.Zimachitika pamene munthu akusowa kapena ali ndi milingo yochepa ya enzyme glucose-6-phosphate dehydrogenase.Enzyme imeneyi imathandiza kuti maselo ofiira a m’magazi azigwira ntchito bwino.Zizindikiro pa nthawi ya hemolytic zingaphatikizepo mkodzo wakuda, kutopa, kupukuta, kuthamanga kwa mtima, kupuma movutikira, ndi khungu lachikasu (jaundice).Kuperewera kwa G6PD kumatengera njira yolumikizirana ndi X ndipo zizindikiro zimakhala zofala kwambiri mwa amuna (makamaka Achimereka aku Africa komanso ochokera kumadera ena a Africa, Asia, ndi Mediterranean).Zimayamba chifukwa cha kusintha kwa majini mu jini ya G6PD.

Glucose-6-Phophate Dehydrogenase (G-6-PDH) ili ndi zigawo ziwiri zofanana kulemera kwa molekyulu. Mndandanda wa amino acid wa monomer wasindikizidwa.G-6-PDH yagwiritsidwa ntchito poyesa nicotinamide adenine dinucleotide ndi pyridine ya minofu. nucleotides.G-6-PDH ikhoza kutsegulidwanso kuchokera ku mayankho a urea-denatured.

Glucose 6-phosphate dehydrogenase ndiye puloteni yofunika kwambiri yowongolera mu gawo loyamba la njira ya pentose phosphate.G-6-P-DH imatulutsa glucose-6-phosphate pamaso pa NADP⁺ kuti apereke 6-phosphogluconate.Polyacrylamide gel electrophoresis, ntchito yodetsa, ndi anti-yeast G-6-PDH antibody immunoblotting kafukufuku wasonyeza kuti G-6-PDH ndi glycoprotein.