Doxycycline Hyclate (24390-14-5)
Mafotokozedwe Akatundu
● Doxycycline Hcl ndi antibacterial spectrum ili pafupi kwambiri ndi Tetracycline ndi Terramycin, koma imakhala ndi zotsatira zabwino, samalani ndi Staphylococcus Aureus ya tetracycline-resistant, oxytetracycline, nthawi yayitali. matenda m`mapapo, pachimake zilonda zapakhosi, mycoplasma chibayo, kwamikodzo thirakiti matenda, magazi poyizoni, bacillary kamwazi, pachimake lymphadenitis, etc. Ndi wotchuka kwambiri Nephropathy wodwala chifukwa cha chiphe zosaonekera kwa impso.
● Doxycycline Hyclate ndi mtundu wa mchere wa hyclate wa doxycycline, mankhwala ophatikizika a tetracycline omwe amasonyeza zochita zowononga tizilombo toyambitsa matenda.Doxycycline hyclate imamangiriza mosinthika ku 30S ribosomal subunit, mwina ku 50S ribosomal subunit komanso, potero kutsekereza kumangirira kwa aminoacyl-tRNA ku mRNA-ribosome complex.Izi zimabweretsa kulepheretsa kaphatikizidwe ka mapuloteni.Kuphatikiza apo, wothandizila uyu wawonetsa kuletsa kwa ntchito ya collagenase.
Kugwiritsa ntchito
Doxycycline Hyclate imagwiritsidwa ntchito pochiza matenda osiyanasiyana a bakiteriya, kuphatikizapo omwe amayambitsa ziphuphu.Doxycycline Hyclate imagwiritsidwanso ntchito popewa malungo.Doxycycline Hyclate amadziwika kuti tetracycline antibiotic.Amagwira ntchito poletsa kukula kwa mabakiteriya.Maantibayotikiwa amangotenga matenda a bakiteriya okha.
| Zinthu | Zofotokozera | Zotsatira |
| Maonekedwe | Yellow crystalline ufa | Zimagwirizana |
| Chizindikiritso | Mtengo wa TLC | Zimagwirizana |
| sulfuric acid reaction mtundu wachikasu umayamba | Zimagwirizana | |
| amapereka zochita za kloridi | Zimagwirizana | |
| PH | 2.0-3.0 | 2.3 |
| Specific absorbance | pa 349nm e(1%) 300~355 | 320 |
| Kuzungulira kwapadera kwa kuwala | -105 ~ -120 ° | -110 ° |
| Zitsulo zolemera: | ≤50ppm | <20ppm |
| Zonyansa zotengera kuwala | pa 490nm ≤0.07 | 0.03 |
| Zogwirizana nazo | 6-epidoxycycline ≤2.0%metacycline ≤2.0% 4-epidoxycycline ≤0.5% (ep5) 4-epi-6-epidoxycycline ≤0.5% (ep5) oxytetracycline ≤0.5% (ep5) zonyansa zina zilizonse ≤0.5% zonyansa zosazindikirika ≤0.1% (ep5) | 1.6% 0.1% Sinapezeke Sinapezeke Sinapezeke Sinapezeke Sinapezeke |
| Ethanol | 4.3-6.0% (m/m) | 4.5% |
| Phulusa la sulphate | ≤0.4% | 0.05% |
| Madzi | 1.4-2.8% | 1.8% |
| Kuyesa | 95.0 ~ 102.0% ( c22h25cln2o8) kutengera anhydrous, mankhwala opanda ethanol | 98.6% |
| Mapeto | Zogwirizana ndi USP32 | |
